The study of molecular markers in oncology has had a great impact in the diagnosis and monitoring of each disease, considering that some of these markers can act as targets for treatment and follow-up, facilitating the early detection of relapses and orienting personalized treatment options.
Molecular cytogenetic studies aimed at the detection of genetic anomalies are available through “in situ hybridization” through the fluorescencia (FISH) and cromógenos (CISH).
FISH is a technique most frequently used for confirmatory oncological hematocrit diagnosis and corresponds to a highly sensitive cytochemical methodology that allows the identification and localization of nucleic acid sequences in morphologically conserved structures. It is based on the specific pairing of two complementary nucleic acid sequences, in which a labeled probe forms a hybrid with the DNA sequence under study that can be visualized through a fluorescence or light microscope.
This methodology is available under a certified platform for the confirmatory diagnosis of hematolymphoid, epithelial and stromal neoplasms and in a permanent scientific partnership with cytogenetic diagnostic centers in Europe.
At present, specialized and novel methodologies with clinical utility in the area of molecular biology are required.
The polymerase chain reaction (PCR) amplification techniques, conventional and in real time, as well as the nucleic acid sequencing, allow the tracking of specific sequences that offer increasingly detailed and secure information in the diagnosis and detection of specific genetic alterations, associated with various oncological diseases.
These diagnostic techniques are useful for a better treatment and monitoring of patients, based on consensus and internationally certified platforms, under scientific advice in partnership with molecular diagnostic centers in Europe.
Type of sample
- Peripheral blood or bone marrow in tube with EDTA anticoagulant (Lilac cap).
- Tissue biopsies included in paraffin.
10 business days (Molecular Cytogenetics)
15 business days (Molecular Biology)